Differential leucocyte alkaline phosphatase activity (LAPA) in chronic myeloid leukaemia (CML) and myeloid leukemoid reaction (MLR).
نویسندگان
چکیده
Leucocyte Alkaline Phosphatase Activity (LAPA) in normal healthy individuals was lound to be in the range 17-110. It was markedly increased in patients with myeloid leukemoid reaction (MLR) in the range 100-220. However it was decreased in patients with chronic myeloid leukaemia (CML) in the range 0-16. Increased LAPA in MLR is indicative of enhanced digestive capability of neutrophils while decreased values in CML are suggestive of defective neutrophil function. LAPA is a diagnostic parameter in differentiating between MLR and CML and also seem to have a prognostic and predictive value for blastic transformation in CML (JPMA 34: 114, 1984).
منابع مشابه
Chronic myelogenous leukaemia (CML)
Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...
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ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 34 5 شماره
صفحات -
تاریخ انتشار 1984